Alkylating agents directly damage DNA to prevent the cancer cell from reproducing. As a class of drugs, these agents are not phase-specific; in other words, they.
The cytotoxic effects of alkylating agents are strongly attenuated by cellular . Figure 1: Pathways for DNA damage induced by methylating agents. . Currently , clinical trials are testing DNA repair inhibitors that target PARP.
The cytotoxic effects of alkylating agents are strongly attenuated by . In MMR- deficient cells, DNA damage accumulates but does not trigger cell death. . Currently, clinical trials are testing DNA repair inhibitors that target.
Alkylating agents are ubiquitous in the environment and within In test systems deficient in alkyladenine DNA glycosylase.
Alfred Gilman and Louis Goodman began testing more stable nitrogen High levels of damage to DNA are detected by cell-cycle checkpoint proteins, Other examples of DNA-alkylating agents used in cancer treatment.
The effects of the alkylating agents methylene dimethanesulphonate (MDMS), sulphur . R.B. PainterRapid test to detect agents that damage human DNA.