HOW DO ALKYLATING AGENTS DAMAGE DNA ANCESTRY

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Alkylating agents directly damage DNA to prevent the cancer cell from reproducing. As a class of drugs, these agents are not phase-specific; in other words, they.

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The cytotoxic effects of alkylating agents are strongly attenuated by cellular . Figure 1: Pathways for DNA damage induced by methylating agents. . Currently , clinical trials are testing DNA repair inhibitors that target PARP.

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The cytotoxic effects of alkylating agents are strongly attenuated by . In MMR- deficient cells, DNA damage accumulates but does not trigger cell death. . Currently, clinical trials are testing DNA repair inhibitors that target.

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Alkylating agents are ubiquitous in the environment and within In test systems deficient in alkyladenine DNA glycosylase.

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Alfred Gilman and Louis Goodman began testing more stable nitrogen High levels of damage to DNA are detected by cell-cycle checkpoint proteins, Other examples of DNA-alkylating agents used in cancer treatment.

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The effects of the alkylating agents methylene dimethanesulphonate (MDMS), sulphur . R.B. PainterRapid test to detect agents that damage human DNA.

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